C4d peritubular capillary staining in chronic allograft nephropathy and transplant glomerulopathy: an uncommon finding
نویسندگان
چکیده
منابع مشابه
Combination of peritubular c4d and transplant glomerulopathy predicts late renal allograft failure.
The histologic associations and clinical implications of peritubular capillary C4d staining from long-term renal allografts are unknown. We identified 99 renal transplant patients who underwent an allograft biopsy for renal dysfunction at least 10 yr after transplantation, 25 of whom were C4d-positive and 74 of whom were C4d-negative. The average time of the index biopsy from transplantation wa...
متن کاملThrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies.
BACKGROUND AND OBJECTIVES This study characterizes the pathologic and clinical relationships of thrombotic microangiopathy (TMA) to antibody-mediated rejection (AMR) in renal allograft biopsies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Consecutive renal allograft biopsies, routinely stained for C4d over a period of 51 months (n=1101), were reviewed. For comparative analysis of histology ...
متن کاملTransplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining.
BACKGROUND AND OBJECTIVES Transplant glomerulopathy (TGP) has been proposed to be a component of chronic antibody-mediated rejection (AMR). We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms. DESIGN, SETTING, PARTICIPANTS,...
متن کاملCapillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection.
Endothelial deposition of the complement split product C4d is an established marker of antibody-mediated acute renal allograft rejection. A contribution of alloantibody-dependent immune reactions to chronic rejection is under discussion. In this study, the association of immunohistochemically detected endothelial C4d deposition in peritubular capillaries (PTC) with morphologic features of chron...
متن کاملSignificance of C4d deposition in antibody-mediated rejection.
The C4d staining as a special tissue marker for humoral immunity has served criteria of pathological diagnosis for antibody-mediated rejection (ABMR) in Banff classification since 2003. However, the sensitivity and specificity of C4d staining have been questioned, and recently, C4d-negative ABMR has been more focused in renal allograft pathology. The aim of this study was to make certain of C4d...
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ژورنال
عنوان ژورنال: Transplant International
سال: 2005
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.2005.00130.x